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The recommended ranges of the drugs plasma concentrations
The recommended ranges of the drugs plasma concentrations druring different stages of surgery are presented below in the tables.
The recommended ranges of the hypnotics and ketamine plasma concentrations*
| Diprivan (mcg/ml) | Thiopental sodium (mcg/ml) | Diazepam (mcg/ml) | Midazolam (ng/ml) | Ketamine (mcg/ml) | |
| During surgery | 2-5 | 10-20 | 0,6-1,0 | 100-200 | 0,7-2,2 |
| Awake | <1,5 | 4,8-7 | <0,5 | <50 | <0,5 |
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The recommended ranges of the opioids plasma concentrations*
| Fentanyl (ng/ml) | Sufentanil (mg/ml) | Alfentanil (ng/ml) | Remifentanil (ng/ml) | |
| Monoanesthesia | 15-30 | 5-10 | 400-800 | — |
| Major surgery | 4-10 | 1-3 | 200-400 | 2-4 |
| Minor surgery | 3-6 | 0,25-1 | 50-200 | 1-3 |
| Spont.breathing | 1-3 | <0,4 | <200 | 0,3-0,6 |
| Analgesia | 1-2 | 0,2-0,4 | 50-150 | 0,2-0,4 |
The recommended ranges of the neuromuscular blocking agents plasma concentrations
| Rocuronium (mcg/ml) | Cisatracurium (mcg/ml) | |
| During surgery | >1,5** | >0,3 |
| Awake | <0,5*** | <0,2 |
References
* Miller R.D. Miller's anesthesia. 7th edition. 2009. Chapter III: Anesthetic Pharmacology.
** Pharmacokinetics and pharmacokinetic/dynamic relationship of rocuronium bromide in humans. / Wierda J.M., Proost J.H., Schiere S., Hommes F.D. // Eur J Anaesthesiol. - 1994. - Vol. 9. P. 66-74.
*** Sal'nikov V.G. Status of peripheral hemodynamic in perioperative period. PhD dissertation abstract. – St.Petersburg, 2010. – 22 p.
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