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The recommended ranges of the drugs plasma concentrations

The recommended ranges of the drugs plasma concentrations druring different stages of surgery are presented below in the tables.

The recommended ranges of the hypnotics and ketamine plasma concentrations*

Diprivan
(mcg/ml)
Thiopental sodium
(mcg/ml)
Diazepam
(mcg/ml)
Midazolam
(ng/ml)
Ketamine
(mcg/ml)
During surgery 2-5 10-20 0,6-1,0 100-200 0,7-2,2
Awake <1,5 4,8-7 <0,5 <50 <0,5
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The recommended ranges of the opioids plasma concentrations*

Fentanyl
(ng/ml)
Sufentanil
(mg/ml)
Alfentanil
(ng/ml)
Remifentanil
(ng/ml)
Monoanesthesia15-305-10400-800Ч
Major surgery4-101-3200-4002-4
Minor surgery3-60,25-150-2001-3
Spont.breathing1-3<0,4<2000,3-0,6
Analgesia1-20,2-0,450-1500,2-0,4

The recommended ranges of the neuromuscular blocking agents plasma concentrations

Rocuronium
(mcg/ml)
Cisatracurium
(mcg/ml)
During surgery >1,5** >0,3
Awake <0,5*** <0,2

References
* Miller R.D. Miller's anesthesia. 7th edition. 2009. Chapter III: Anesthetic Pharmacology.
** Pharmacokinetics and pharmacokinetic/dynamic relationship of rocuronium bromide in humans. / Wierda J.M., Proost J.H., Schiere S., Hommes F.D. // Eur J Anaesthesiol. - 1994. - Vol. 9. P. 66-74.
*** Sal'nikov V.G. Status of peripheral hemodynamic in perioperative period. PhD dissertation abstract. Ц St.Petersburg, 2010. Ц 22 p.


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